암 노화 연구실 (LABORATORY OF CARDIAC AND AGING)

연구주제

  • Our laboratory is concerned with problems in molecular biology, cell biology, oncology and medicine.
  • Many of our studies involve studying gene functions in relation with cancer and aging to provide molecular explanation and to intercept the disease progression.

PI 및 연구원 소개

  • 교  수: Jeong A. Han, M.D., Ph.D.
  • 연구원 : JPh.D. Candidates, So Ra Kim, M.S., Hyeon Ju Lee, M.S., Jeong Mi Kim, M.S., M.S. Candidates, Da Bi Shin, Soo Hyeon Ji

연구 성과 소개

  • Lee HJ, Kim JM, Kim KH, Heo JI, Kwak SJ, Han JA*. Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53. Cell Death Differ. 2014 Accepted.
  • Kim SY, Kang HT, Han JA, Park SC. The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking. Aging Cell. 2012 Dec;11(6):1102-1109.
  • Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA*. Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner. Exp Mol Med. 2012 Sep 30;44(9):536-644.
  • Choi EM, Kim SR, Lee EJ, Han JA*. Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. Biochim Biophys Acta – Mol Cell Res. 2009, 1793(8), 1354-1365.
  • Kim SR, Park JH, Lee ME, Park JS, Park SC*, Han JA*. Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner. Mech Ageing Dev. 2008, 129(12), 706-713.
  • Lee EJ, Choi EM, Kim SR, Park JH, Kim H, Ha KS, Kim YM, Kim SS, Choi M, Kim JI, Han JA*. Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. Exp Mol Med. 2007, 39(4), 469-476.
  • Lee J, Kosaras B, Aleyasin H, Han JA, Park DS, Ratan RR, Kowell NW, Ferrante RJ, Lee SW, Rye H. Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J. 2006, 20(13), 2375-2377.
  • Choi EM, Kwak SJ, Kim YM, Ha KS, Kim JI, Lee SW, Han JA*. COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. Exp Mol Med, 2005, 37(3), 199-203.
  • Choi EM, Heo JI, Oh JY, Kim YM, Ha KS, Kim JI, Han JA*. COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis. Biochem Biophys Res Commun. 2005, 328(4), 1107-1112.
  • Han JA, Kim JI, Ongusaha PP, Hwang DH, Ballou LR, Mahale A, Aaronson SA, Lee SW. p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J. 2002, 21(21), 5635-5644.