Experimental ischemic stroke: I have studied about neuronal damage and protection in the ischemic brain.
Neurogenesis: I have studied on endogenous neurogenesis in the brain during normal aging or in the damaged brain.
CNS aging: I have examined the morphological changes with neurosubstances in the brain during normal aging.
Medicines for neuroprotection, neurogenesis and anti-aging in the CNS: I have examined many medicines including extracts of foods and plants that protect neuronal damage or aging and enhance neurogenesis.
PI 및 연구원 소개
Neurobiology is an integral part of understanding of the brain´s structures and functions. The Department of Neurobiology is devoted to the study of the brain (its organization and functioning in health and diseases). To address a complete understanding of the brain´s functions, we adopt an integrative approach ? the techniques and concepts used in our investigations are taken from a wide range of disciplines, including, basically, neuroanatomy, additionally, neurophysiology, molecular biology, biochemistry, cell biology, biophysics, and behavioral neurobiology. In the Department of Neurobiology, aging-related neurodegeneration and cerebrovascular disease have become major concerns in researches. Focus of the research is on neuronal damage and protection in the ischemic brain, on endogenous neurogenesis in the brain during normal aging or in the damaged brain, on the morphological changes with neurosubstances in the normal aged brain, and on the medicines for neuroprotection, neurogenesis and anti-aging in the CNS.
연구 성과 소개
Maeng YS, Choi HJ, Kwon JY, Park YW, Choi KS, Min JK, Kim YH, Suh PG, Kang KS, Won MH, Kim YM, Kwon YG. Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood. 2009 Jan 1; 113(1):233-43. PMID: 18832656.
Yoo DY, Kim W, Lee CH, Shin BN, Nam SM, Choi JH, Won MH, Yoon YS, Hwang IK.Melatonin improves d-galactose-induced aging effects on behavior, neurogenesis,and lipid peroxidation in the mouse dentate gyrus via increasing pCREBexpression. J Pineal Res. 2012 Jan;52(1):21-8. doi: 10.1111/j.1600-079X.2011.00912.x. Epub 2011 Jul 1. PMID: 21718363.
Hwang IK, Yoo KY, Kim DW, Lee CH, Choi JH, Kwon YG, Kim YM, Choi SY, Won MH.Changes and Expression of Mitochondrial Peroxiredoxin and Thioredoxin in Neurons and Glia and Their Protection in Experimental Cerebral Ischemic Damage. Free RadicBiol Med. 2010 May 1;48(9):1242-1251. Epub 2010 Feb 12. PMID: 20156553.
Hwang IK, Eum WS, Yoo KY, Cho JH, Kim DW, Choi SH, Kang TC, Kwon OS, Kang JH, Choi SY,Won MH.Copper chaperone for Cu,Zn-SOD supplement potentiates the Cu,Zn-SOD function of neuroprotective effects against ischemic neuronal damage in the gerbil hippocampus. Free RadicBiol Med. 2005 Aug 1; 39(3):392-402. PMID: 15993338.
Lee CH, Park JH, Yoo KY, Choi JH, Hwang IK, Ryu PD, Kim DH, Kwon YG, Kim YM, Won MH.Pre- and post-treatment with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress. Exp Neurol. 2011 Jun;229(2):450-9. Epub 2011 Mar 31. PMID: 21458451.